Friday, November 30, 2012

Grow Your Business With These Simple Marketing With Email Tips ...

E-mail marketing is one of the most effective methods of advertising today. If you?re thinking about getting into email marketing then use all of the tips in this article to help you get started today.

Use the information you already know to create a much better shopping experience. If a customer is filling out an order form linked from an opt-in email, automatically fill in the information you already know about the customer. This saves time and increases the likelihood that your customers will buy something.

In order to cover all of your bases when you market through email, make use of multi-part messages. These emails include both plain and HTML texts, so they will be displayed no matter the option your recipient favors. This is worth the extra step because someone who only wants plain-text will most likely unsubscribe from an email list that is only HTML.

TIP! Use passive and active feedback to make your email marketing better. Active feedback is exactly what you would expect: asking reader opinions in the form of surveys or questionnaires.

If you plan on utilizing email marketing as a promotional strategy, it is crucial that everyone on your subscriber list has authorized you to send them emails. If you do not do this, you will be accused of sending spam, and it may cause you to lose some customers.

Have goals with your audience. Why would your readers want to sign up for your email list? Once you have the answer, use it to your advantage. You should also be sure you have a subscribe link sent out in your email. This will help your existing customers send a link to their friends. This allows your database to grow organically.

Be sure you?ve digested the valuable information detailed in this article. You should either go through these paragraphs again, or bookmark this article for easy access. That way you will have no trouble applying the advice presented here for successfully manifesting your ambitions.

TIP! Keep in mind that the sole purpose of building an email list is to sell your wares. Therefore, every email you send should increase the likelihood that subscribers will buy.

Other articles you might like;

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Source: http://elektrotehnickifakultet.com/grow-your-business-with-these-simple-marketing-with-email-tips.html

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Will 'Killing Them Softly' Be a Hit at the Box Office?

From Killing Them Softly to Silver Linings Playbook, get the scoop on what's playing in theaters!

Source: http://www.ivillage.com/movie-reviews-what-see-weekend/1-b-415949?dst=iv%3AiVillage%3Amovie-reviews-what-see-weekend-415949

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Nicole Richie and Harlow?s Matching Fedoras

On Nov. 23, the fashion designer and her 4?-year-old synchronized their sweet styles with floppy fedoras at the Yo Gabba Gabba Live! show.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/D10mANWvQB8/

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What is 'Best of the Rest' basketball? | Daily Bulldog

Posted by admin ? November 29, 2012 ?

FARMINGTON - If you?re not playing interscholastic basketball for Mt. Blue (Freshmen, Junior Varsity or Varsity) you are eligible to participate in Farmington Recreation Department?s high school intramural program.

?Best of the Rest? is an opportunity for teenaged boys and girls to continue playing organized, competitive basketball at the Farmington Community Center. Each team will be comprised of a Senior or upperclassman chosen to ?draft? or select other students from a pool of registered players that attend a tryout at the Recreation Department.

While games are officiated, the pace of the action is sustained by eliminating many of the minor free throw shooting interruptions and automatically tacking on those points as play continues. Begun by Coach Fred Conlogue in 2008, this up tempo version of the game is fan friendly as fellow students and school players alike drop by to catch some of the action.

Depending on the response and level of interest indicated by available high school students, the Rec. Dept. will hold an evening of open scrimmages for prospective players in early December so captains can evaluate the talent pool. That will be followed by a player draft the following week to assemble the teams. Any students that go unselected will have their Registration Fee returned to them.

Each season four teams of up to eight players compete in a Round Robin balanced schedule that has them facing each other three times before the single elimination playoffs get underway. Games are scheduled for three time spots at the Community Center; the 7:30 Thursday night feature game of the week and a Monday and Wednesday afternoon game with tipoff at 3:00 p.m.. Currently the schedule, with Pre-season, begins in December and runs through January into
early February.

For more information contact the Farmington Recreation Department at 778-3464 or drop by the office located at the Community Center.

This is not a Mt. Blue RSD sponsored activity, but its information is being distributed through the public schools as a community service. All costs associated with this flyer are paid for by the Farmington Recreation Department.

Source: http://www.dailybulldog.com/db/sports/what-is-best-of-the-rest-basketball/

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Source: http://www.dreambuilderpro.com/social/activity/p/6364/

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Analysis: Crisis tests Egyptians' constitution

Mohamed Abd El Ghany / Reuters

Members of Egypt's constituent assembly discuss during the last voting session on a new draft constitution at the Shoura Assembly in Cairo Nov. 29, 2012. An assembly drafting Egypt's new constitution voted on Thursday to keep the principles of Islamic law as the main source of legislation, unchanged from the previous constitution in force under former President Hosni Mubarak.

By Jim Maceda, NBC News
News analysis

CAIRO, EGYPT ? Constitutions are often messy affairs. Our own Constitutional Convention, in 1787, was convened secretly, behind guarded doors. Many delegates were suspicious it was all a ploy by George Washington to wrest power from personal freedoms.? Some delegates walked out before the hard work even began. And once the writing was finished, four of the 13 states?didn't?even ratify it.

But few constitutions have generated the road bumps ? or media coverage ? that Egypt?s new, post-Hosni Mubarak constitution has.?


There are several reasons why this particular document is getting so much attention. It?s not only because it would detail Egypt?s future government and the values upheld by it. All constitutions do that. What makes this constitutional process unusual is the way in which it?s been hijacked by the political crisis playing out in Egypt today ? a crisis that pits Islamists, led by Egypt?s President Mohamed Morsi, against their opponents, led primarily by Egypt's judges.

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Egypt?s constitution stymied by legal challenges?

When Egypt?s first 'Constitutional Assembly,' or CA, met to begin its work, the 100 delegates knew they were embarking on something historic ? for the first time in Egypt?s long history, they were tasked to produce a document that showcased and protected Egypt?s fledgling democracy.? But the euphoria didn't last long. Within months, Egypt?s Islamist-laden parliament ? the body that created the CA ? was dissolved by court order, driven by mostly Mubarak-appointed judges.

Shortly thereafter, a series of legal challenges threatened the constitution-writing panel itself. By this time it had become clear to non-Islamist delegates that the Islamists on the panel were determined to write a defense of Islamic aspirations. ?Over one-quarter of them ??representing secular Egyptians, liberals,? Christians and other minorities ? walked out.? It appeared the panel, by then entirely Islamist, would be dissolved by the judges.

It?s with this backdrop that Morsi made public his controversial decree last Thursday. In a sweeping retort to the judges, he declared that his every ruling, the remaining upper house of parliament, and the CA, all be above the law.? He gave the CA two more months to complete its work and offer up a final document for ratification. That, as we now know, triggered the turmoil in the streets which some are already calling Egypt's 'Second Revolution.' Two young Egyptians have been killed, and hundreds wounded in clashes between pro- and anti-Morsi protesters and riot police. But the international media still calls it a 'constitutional crisis.'

Morsi and his Muslim Brotherhood colleagues then decided to go for broke, and gamble that a pro-Islamist constitution rammed through the CA would be ratified by the Egyptian people.

This is not a slam dunk. More than 200,000 opponents demonstrated in a massive show of support in Tahrir Square on Tuesday night, calling Morsi?s decree ? and the new constitution ? illegal.?

"This is nonsensical and one of the steps that shouldn't be taken, given the background of anger and resentment to the current constitutional assembly," opposition leader and former head of the Arab League, Amr Moussa, told?Reuters.?

?You had your revolution. This one is ours?
Another large anti-Morsi protest is now scheduled for Friday. And the Muslim Brotherhood is organizing its own 'million man' march on Saturday, one it now says will not end at Tahrir Square to avoid any confrontation with protesters who have turned the Square into a ?Muslim Brotherhood Free Zone?. ?

Khaled Mahmoud, a 26-year-old volunteer medic who has set up a makeshift clinic for wounded protesters just off the Square, told NBC News he would tell Saturday?s would-be Muslim Brotherhood protesters, "Step back. You had your revolution. This one is ours."

But now?? in yet another morphing from its intended role ? Egypt?s new constitution has become a pawn in Morsi?s exit from all the chaos. The Assembly, which, again, had two more months to work, is racing through its completion in just 48 hours.

As the CA put each article to a vote Thursday afternoon, liberal delegate Mohamed Mohyeldin objected.

"There is a rush in the voting, we should slow down the pace, so that we do not give the impression that we have a problem that we are afraid of and are running away from. We have two months."

But on State TV the speaker, Hossam al Gheryani, said in reply, "We are waiting for those who want to return?we would be happy for them to participate?[but] there are those who said they wanted nothing to do with this Constitutional Assembly."

Bishop Paula was among the angry delegates who refused to return and vote Thursday.

"We know already the result of the vote because of the unbalanced [Islamist] formation of the Assembly. The result is settled whether we go or not," said the representative of the Orthodox Church on live TV.?

Egypt to vote on new constitution

And what about the constitution itself? As it rolls off a government website, it appears to be in every way the expression of a pro-Islamist society about half the nation hoped for, and the other half feared. It would not only make conservative Sharia law the law of the land, but expand that, constitutional experts here say, to "dangerous" levels. Besides Islam, only Christianity and Judaism ? fellow Abrahamic religions ? would be recognized.?

Ominously, its Article 11 reads: "The State and society shall be committed to safeguarding and protecting ethics and public morals." One expert on Egyptian TV warned that this would lay the groundwork for the appearance of "vice and virtue" (vigilante) squads.

Morsi?s speech to the nation Thursday night will explain the reasons behind his decree, and no doubt set the timeline for a national vote on the new, fast-tracked constitution. He has 30 days to conclude the ballot. If it passes ? and the Muslim Brotherhood has yet to lose a vote ? it will allow Morsi to remove a large monkey from his back. He could then transfer his legislative powers to a new (likely Islamist) parliament, elected within two months of ratifying the constitution.

So, in theory, the current ?constitutional crisis? could be over in three months. Or there could be a new, even more turbulent one, further splitting apart the nation.

Jim Maceda is an NBC News foreign correspondent based in London and currently on assignment in Cairo. He has covered the Middle East since the 1970s.

More world stories from NBC News:

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Source: http://worldnews.nbcnews.com/_news/2012/11/29/15545841-analysis-crisis-tests-egyptians-constitution?lite

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AirWatch Partners with Siemens for Unified Communications ...

Mobile device management (MDM) provider AirWatch?has partnered with Siemens Enterprise Communications?on a deal the companies hope will help relieve the stresses of implementing mobile unified communications (UC) and managed mobility solutions. The referral partnership will provide Siemens Enterprise Communications with AirWatch?s mobile security, device management, and application management solutions, which, according to the company, will make it easier for customers to deploy, manage and use mobile UC. Here are the details.

The partnership enables Siemens? OpenScape unified communications platform to provision their applications to mobile devices over the air. AirWatch CEO John Marshall weighed in to explain, ?That means we will continue to simplify BYOD initiatives by bringing both secure mobile device management and unified communications together.? The integration of both solutions attempts to simplify deployment, management and ongoing support for these tools across multiple device types and mobile operating systems from one single console.

AirWatch has been working with Siemens Enterprise Communications for the past couple of months through AirWatch?s internal network of customers and relationships. ?By working with key partners, this announcement is another step in our overall mobile enterprise integration,? said Marshall. ?The partnership is a major win for Siemens and AirWatch, especially from a BYOD perspective.?

?Mobility is a core part of enterprise communications, and the BYOD trend has reinforced the need for CIOs to proactively manage and support enterprise tools on a variety of consumer-driven devices,? according to a statement by Siemens Enterprise Communications Chief Commercial Officer Chris Hummel. ?Partnering with AirWatch provides our customers with a proven solution to manage their mobile OpenScape solutions.?

AirWatch has been working to recruit managed service providers. The company also recently had a patent infringement lawsuit filed against it by Good Technology.

Read More About This Topic

Source: http://www.mspmentor.net/2012/11/29/airwatch-partners-with-siemens-for-unified-communications/

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Senators push Obama to propose clean gasoline rules (reuters)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

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Rules devised for building ideal protein molecules from scratch

ScienceDaily (Nov. 28, 2012) ? By following certain rules, scientists can prepare architectural plans for building ideal protein molecules not found in the real world. Based on these computer renditions, previously non-existent proteins can be produced from scratch in the lab. The principles to make this happen appear this month in Nature magazine.

The lead authors are Dr. Nobuyasu Koga and Dr. Rie Tatsumi-Koga, a husband-and-wife scientific team in Dr. David Baker's lab at the University of Washington Protein Design Institute.

The project benefited from hundreds of thousands of computer enthusiasts around the world who adopted Rosetta@home for simulating designed proteins.

Protein molecules start as an unstable, high energy chain of amino acids. This chain then begins folding into various shapes to try to achieve a stable, low energy state. The end result is its distinctive molecular structure. Rosetta@home volunteers helped the project team to plot this energy landscape from protein structure predictions.

"The structural options become fewer as the interactions that stabilize the protein selectively favor one folding pattern over others," explained Koga.

"This decline in conformation options to eventually achieve a unique, ordered structure is called a funnel-shaped energy landscape," he said, drawing a tornado-like figure on a whiteboard. The researchers came up with guidelines for robustly generating this type of energy landscape.

According to Tatsumi-Koga, these rules require the interactions among the residues in the protein's amino acid chain to consistently favor the same folded conformation in forming its molecular shape. This is made possible, for example, by defining whether a specific unit will form a "right-handed" orientation or its mirror image, and disfavor others.

The researchers, she said, synthesized the proteins they had originally designed and tested "in silico" (on the computer) and physically characterized them through "in vitro" (laboratory test tube) experiments.

They also compared the molecular structures of the computer models with these laboratory-derived proteins to see how well they matched.

Koga stressed that the project looked strictly at protein structure. He smiled as he said his group was striving toward a "platonic ideal," a reference to Plato's theory of perfect forms.

In our imperfect material world, proteins are not always optimized for their stability, but can be beset by bulges, kinks, strains, and improperly buried parts. Many diseases arise from protein malformations.

During this project, the researchers achieved a library of five ideal structures, but since filing their report have added several more.

To make them accessible to other scientists, the designs have been deposited in the Research Collaboratory for Structural Bioinformatics and the lab analysis of their chemical structure was put in the Biological Magnetic Resonance Database.

The team was not attempting to create specific new proteins that could carry out particular activities.

However, their design principles and methods, according to their report, should allow the ready creation of a wide range of robust, stable, building blocks for the next generation of engineered functional proteins.

Such proteins would be custom-made for the task, instead of repurposed from proteins with unrelated functions. The hope is that engineered proteins will be useful for drug and vaccine development, especially for formidable viruses like HIV or rapidly changing ones, like the flu.

Proteins designed to exact specifications might also prove therapeutically useful in cleaving mutated genes, and for speeding up chemical reactions important in industry and environmental reclamation.

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Story Source:

The above story is reprinted from materials provided by University of Washington. The original article was written by Leila Gray.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nobuyasu Koga, Rie Tatsumi-Koga, Gaohua Liu, Rong Xiao, Thomas B. Acton, Gaetano T. Montelione, David Baker. Principles for designing ideal protein structures. Nature, 2012; 491 (7423): 222 DOI: 10.1038/nature11600

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/Q1RqmNvqLVg/121129093949.htm

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Thursday, November 29, 2012

Just When Was It A Great Idea To Take Out A Cash Advance ...

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Source: http://www.dgstradinginc.com/just-when-was-it-a-great-idea-to-take-out-a-cash-advance/

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UN nuclear chief urges more cooperation from Iran

VIENNA (AP) ? The head of the U.N. nuclear agency says he cannot provide a "credible assurance" for Tehran's claims that all of its atomic activities are peaceful.

Speaking Thursday at a board meeting of the 35-country International Atomic Energy Agency, Yukiya Amano also expressed concern over Iran's "activities" at Parchin, southeast of Tehran.

His experts want to visit the site amid suspicions that it was used for secret tests related to nuclear weapons developments. His language is diplomatic shorthand for an alleged cleanup at the site.

Iran denies any interest in nuclear weapons and says it never tried to develop them. It dismisses concerns that it is enriching uranium for possible use as the core of a warhead, saying it wants only to produce reactor fuel.

Source: http://news.yahoo.com/un-nuclear-chief-urges-more-cooperation-iran-110217267.html

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In communist Cuba, the tax man cometh

HAVANA (Reuters) - Most Cubans have not paid taxes for half a century, but that will change under a new code starting January 1.

The landmark regulations will change the relations of Cubans with their government and are a signal that market-oriented reforms, launched since President Raul Castro succeeded his brother, Fidel Castro, in 2008, are here to stay.

The recently published code constitutes the first comprehensive taxation in Cuba since the 1959 revolution abolished just about all taxes.

In the 1990s after the collapse of the Soviet Union, the country's main benefactor, the Cuban government imposed a few scattered taxes, but mostly preferred to maintain low wages so it could fund free social services.

The government's free market reforms introduced over the last two years, are designed to encourage small businesses, private farming and individual initiative, along with plans to pay state workers more. Under the new tax code the state hopes to get its share of the proceeds.

The government also envisions replacing subsidies for all with targeted welfare, meaning that the largely tax-free life under a paternalistic government is on its way out.

"This radically changes the state's relationship with the population and taxes become an irritating issue," said Domingo Amuchastegui, a former Cuban intelligence analyst who lives in Miami and writes often about Cuba.

The new code covers 19 taxes, including such things as inheritance, environment, sales, transportation and farm land, various license fees and three contributions, including social security.

A sliding scale income tax - from 15 percent for earnings of more than 10,000 pesos (about $400) annually, to 50 percent for earnings of over 50,000 pesos, (about $2,000) - adopted in 1994, remains in the new code for the self-employed, small businesses and farms, but it also includes a series of new deductions to stimulate their work.

TAX DEDUCTIONS

For example, farmers may deduct up to 70 percent of income as costs, and small businessmen, who are taxed by income not profit, up to 40 percent, plus various fees and secondary taxes they pay.

A labor tax of 20 percent will gradually be reduced to 5 percent by 2017, and small businesses with five employees or less are exempt.

Eventually all workers will pay income taxes as well as a new 2 percent property tax, but both measures are suspended until "conditions permit" them to go into effect.

The government admits, with an average pay of about 450 pesos per month, or $19, many workers do not earn enough to make ends meet.

"They collect taxes for all these things around the world, it's normal," said Havana economist Isabel Fernandez.

"But here we face two problems. On the one hand we are not used to paying for anything and on the other our wages are so low we can't spare a single peso," she said.

Under the old system, large and small state-run companies, which accounted for more than 90 percent of economic activity, simply handed over all their revenues to the government, which then allocated resources to them.

The reforms call for large state-run businesses to be moved out of the ministries and become more autonomous.

Under the new tax system they will pay a 35 percent tax on their profits, but can take advantage of a myriad of deductions ranging from amortization and travel to sales taxes, insurance and environmental protection.

Many smaller businesses will become cooperatives or be privately leased and taxed based on income.

The state-owned Cuban National News Agency said Cuba had studied the tax systems of a number of other countries, including several with capitalist economies.

"The experiences of China, Vietnam, Venezuela, Brazil, Spain and Mexico were taken into account, but they were refined to the particularities and conditions of the island," the new agency said.

The new code is not etched in stone - it can be amended each year as part of the annual budget passed by the National Assembly, and temporarily modified for different reasons by the executive branch of government.

"Like the reforms, it is a work in progress, a work that has barely begun and will take time to put in place," said a Western businessman who has worked in Cuba for almost two decades.

But, he added, "this is of course a major step forward toward the 21st century and a modern state."

(Editing by Jeff Franks, David Adams and Paul Simao)

Source: http://news.yahoo.com/communist-cuba-tax-man-cometh-060046328.html

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Yale College Successful Open Evening

Yale College students and staff welcomed a record number of visitors to the College for their open evening which began with Christmas tree light switch on by Entry Level learner, Jason Coles with The Principal and Carol Singing by Yale Choir and Performing Arts students.

The well attended advice event was advertised on local radio by Yale learners Lewis Owen, Joshua Collins, Alys Jones, Beth Parry and Lexi Jakk studying for their ?Agored Certificate in Radio Broadcasting?.

Student ambassadors welcomed learners to both campuses of Yale College from throughout the region to launch their full-time course prospectus for 2013-14 entry. Shuttle buses ran between campuses offering an opportunity to view the College?s outstanding facilities and attend workshops and demonstrations.

Course guidance and student support information as well as Yale?s highly regarded careers advisors were on hand to help students choose from the wonderful array of opportunities offered by the College which will formally merge with Deeside College in August 2013.

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Source: http://www.yale-wrexham.ac.uk//news/yale-college-successful-open-evening/

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Source: http://farleykirby271.typepad.com/blog/2012/11/daily-tips-for-business-architecture-and-interior-design.html

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Microsoft Sets The Record Straight, Says The Windows Phone 7.8 Update Is Coming In Q1 2013

windows-phone-1Windows Phone 8 has made its fair share of headlines lately but there hasn?t been has much official chatter about Windows Phone 7.8, the update intended to bridge the feature gap between older and newer Windows Phones. Well, consider that quiet streak broken ? Microsoft confirmed today the the 7.8 update would begin rolling out in the first quarter of 2013, with devices running the revamped build poised to launch soon.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/6R9OX7bos6k/

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Beaches back after Grand Canyon floods

Sandy beaches have reappeared more than 100 miles (160 kilometers) downstream of Glen Canyon Dam, an early measure of success for a massive flood last week designed to rebuild habitat along the Colorado River in the iconic Grand Canyon.

However, it will be weeks before scientists know whether the six days of high flows realized the Department of the Interior's goals of moving more than 500,000 metric tons of sediment down the canyon.

"Surely there are new white sandbars in a lot of places, but what we have learned from doing this in the past is that the devil is in the details," said Jack Schmidt, chief of the U.S. Geological Survey's Grand Canyon Monitoring Center. Test floods in 1996, 2004 and 2008 had some unintended consequences, such as increasing the population of predatory non-native trout.

Initial tests
The department ordered the flood, released in a gush from the Glen Canyon Dam starting Nov. 19, to help create beaches and back eddies for campers, rafters and native fish. Since the dam was built in 1966, the only sediment sources for the Grand Canyon are the naturally flowing Little Colorado and Paria rivers, which feed into the Colorado River below the dam. A popular tourist destination, the canyon's beaches and wildlife depend on sand and mud carried by the Colorado River.

USGS researchers spent the Thanksgiving holiday camped along the river monitoring the flood, Schmidt said. Their samples will help determine if the floodwaters actually moved suspended sediment downriver, among other tests, he said.

A group from the National Park Service and the USGS left Monday to float downriver and download before-and-after images from cameras mounted in the canyon and collect additional samples. A preliminary report on the flood's aftermath will be presented at a stakeholders meeting in January 2013. [Related: The Grand Canyon in Pictures ]

"Now starts the hard work of figuring out and understanding the nature of the process that went on during the flood and the environmental impact of the flood," Schmidt told OurAmazingPlanet.

First new beaches
National Park staff at Phantom Ranch, a Colorado River crossing with cabins and a campground more than 100 miles (160 km) downstream of the dam, reported new sand at two nearby beaches, said Jan Balsom, deputy chief of science and resource management for Grand Canyon National Park. Roy's Beach, on river right just upstream of Phantom Ranch, has sand for the first time in a number of years, she said. Cremation Camp, a rafter camp upstream on river left, also has new beach sand.

  1. Science news from NBCNews.com

    1. Scientists are skeptical about Bigfoot DNA report

      Genetic testing confirms the legendary Bigfoot is a human relative that arose some 15,000 years ago ? at least according to a press release issued by a company called DNA Diagnostics detailing supposed work by a Texas veterinarian.

    2. YouTube anaconda vomited goat, not cow
    3. Blue whales use ballet to trick their prey
    4. Atom smasher creates new kind of matter

"We were hoping to see positive results in the first 60 miles (below the dam), and it looks like we're seeing positive results downstream as well," Balsom told OurAmazingPlanet. "Certainly, the initial indications are anecdotal and fairly random, but we're really excited we got the flow off and we're very hopeful we're going to see positive results throughout the system."

The high-flow release plan was announced in May by Secretary of the Interior Ken Salazar. Developed after more than 16 years of planning and testing, the strategy allows Grand Canyon flood releases on short notice, without extensive environmental review or planning, through 2020. The order calls for flows from 31,500 to 45,000 cubic feet (892 to 1,274 cubic meters) per second for up to 96 hours in March through April and October through November. Floods during the March through April period are delayed until 2015 to reduce the population of the invasive rainbow trout, which spawn in the spring.

Reach Becky Oskin at boskin@techmedianetwork.com. Follow her on Twitter @beckyoskin. Follow OurAmazingPlanet on Twitter @OAPlanet. We're also on Facebook and Google+.

? 2012 OurAmazingPlanet. All rights reserved. More from OurAmazingPlanet.

Source: http://www.msnbc.msn.com/id/49986237/ns/technology_and_science-science/

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UCI program fights cancer with cancer - The Orange County Register

Military metaphors are hard to avoid when describing the work in Daniela Bota's lab.

Petri dishes become training camps, where cells taken from patients "learn" to attack a patient's brain tumor.

Dr. Daniela Bota is conducting human trials of possible brain-cancer vaccines, an example of a trend known as personalized medicine. She is pictured with images of brain tumors.

MINDY SCHAUER, THE ORANGE COUNTY REGISTER

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Then, they are re-injected into the patient to seek out and destroy the enemy.

Bota, a UC Irvine neuro-oncologist, is conducting three separate human trials of brain tumor vaccines, with a fourth on the horizon.

And all four are potentially significant advances in the rapidly expanding realm of "personalized medicine" ? drafting a patient's own cells in the fight against disease.

"It's the wave of the future," Bota told a recent visitor to her lab, where the brains of laboratory mice bred to grow human tumors are revealing the tumors' secrets ? and their vulnerabilities.

The clinical trial of the training-camp treatment, known as DCVax, is aimed at patients whose brain tumors have been surgically removed.

Parts of the patient's tumor cells mingle in the petri dish with immune cells, known as dendritic cells, strained from the patient's blood.

"We teach the dendritic cells to fight the tumor," Bota said. "They go and interact with the other immune cells. Everybody gets the message."

While follow-up radiation and chemotherapy can extend patients' lives, it typically fails to remove all cancer cells. Beefing up the patient's immune cells just might.

Two other trials target proteins found on the surface of cancer cells. Like a rallying flag, they summon souped-up immune cells to tear the tumor apart.

"Chemotherapy attacks normal cells," Bota said, leading to unwanted side effects, such as memory loss.

Her approach takes sharper aim at tumor cells.

"A majority of patients have almost no side effects," she said. "There's a much better tolerance than (with) traditional therapies."

A fourth trial awaiting approval by the Food and Drug Administration would deploy an even broader arsenal against tumors.

Tumor cells from one patient along with those of three others will be used to arm immune cells with the power to recognize and attack a variety of tumor types ? defeating cancer's ability to mutate rapidly and camouflage itself from the immune system.

Earlier this year, Bota received special permission from the FDA to try out the treatment on a terminally ill patient.

"The median survival was probably two months or less," she said, for patients in his condition.

He was treated in March. And the patient is still alive as 2012 draws to a close, despite the cancer that threatened to end his life when the year was just getting started.

"He's largely out-survived his expected survival," she said.

Bota and her fellow researchers are careful to avoid leaping to conclusions based on results from a single patient.

Still, the man's survival is encouraging, and could bode well for the larger trial to come.

UC Irvine's Comprehensive Brain Tumor Program has been growing steadily in recent years, she says, first with Dr. Mark Linskey and later Bota's research partner, neuro-oncologist Jose Carrillo.

More recently, neurosurgeons Johnny Delashaw and Frank Hsu joined the team.

"We're actually becoming one of the biggest vaccine programs in the whole country for brain tumors," Bota said. "We have three very strong brain-tumor neurosurgeons, definitely moving us forward at the speed of light."

She is seeking brain cancer patients for all three trials now under way, and the studies should remain open for the next one to three years.

"If any of those studies give positive results, we'll hopefully have one more gun in the arsenal to be fighting the tumor," she said.

Bota said she hopes to obtain permission to begin the fourth trial by spring. It would become the first trial of the vaccine, known as ERC 1671, in the United States, although it is already available in Europe.

Contact the writer: 714-796-7865 or pbrennan@ocregister.com.


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Source: http://www.ocregister.com/news/cells-378943-tumor-patient.html

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Apple iPad mini Wi-Fi + Cellular (AT&T) Review

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Tue Nov 27
"Apple iPad mini Wi-Fi + Cellular (AT&T) Review" LAPTOP Magazine 1:45 PM

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Source: http://www.macsurfer.com/redirr.php?u=742999

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